Matteo Floris è Professore Associato di Genetica Medica presso il Dipartimento di Scienze Biomediche dell’Università di Sassari; è stato Ricercatore presso il Dipartimento di Bioscienze del CRS4 – Centro di Ricerca e Sviluppo in Sardegna (Pula, CA) e Ricercatore presso l’IRGB-CNR di Monserrato.
Laureato in Chimica e Tecnologie Farmaceutiche presso l'Università degli Studi di Padova (nel Novembre 2003), ha conseguito poi un Postgraduate Certificate in Bioinformatics presso l'Università di Koeln (Germania) nel Marzo 2005, un Dottorato di Ricerca in Biochimica presso l'Università “La Sapienza” di Roma nel Marzo 2011 e un secondo Dottorato di Ricerca in Genetica Medica presso l'Università degli studi di Sassari.
Gli interessi principali e le attività di Ricerca ruotano intorno allo studio, la creazione e la applicazione degli strumenti computazionali in ambito biomedico e genomico.
Pubblicazioni e prodotti della ricerca:
1.Torresi Claudia et al. The evolution of African swine fever virus in Sardinia (1978 to 2014) as revealed by whole genome sequencing and comparative analysis. TRANSBOUNDARY AND EMERGING DISEASES (2020) doi:10.1111/tbed.13540.
2.Sanges Francesca, Floris Matteo et al. Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis. BMC CANCER 20, (2020).
3.Orrù Valeria et al. Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. NATURE GENETICS (2020) doi:10.1038/s41588-020-0684-4.
4.Lodde Valeria et al. Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases. BIOMOLECULES 10, 1044 (2020).
5.Idda Maria Laura, Soru Dorian & Floris Matteo. Overview of the First 6 Months of Clinical Trials for COVID-19 Pharmacotherapy: The Most Studied Drugs. FRONTIERS IN PUBLIC HEALTH 8, (2020).
6.Floris Matteo et al. MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia. BMC CANCER 20, 234 (2020).
7.Floris Matteo et al. Direct-to-Consumer Nutrigenetics Testing: An Overview. NUTRIENTS 12, 566 (2020).
8.Serra Rita, Floris Matteo et al. Novel mutations in c2orf71 causing an early onset form of cone-rod dystrophy: A molecular diagnosis after 20 years of clinical follow-up. MOLECULAR VISION 25, 814–820 (2019).
9.Comi Michela et al. Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10). CELLULAR & MOLECULAR IMMUNOLOGY (2019) doi:10.1038/s41423-019-0218-0.
10.Abdouh Mohamed et al. Colorectal cancer-derived extracellular vesicles induce transformation of fibroblasts into colon carcinoma cells. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 38, 257 (2019).
11.Uva Paolo et al. miRNA-135b Contributes to Triple Negative Breast Cancer Molecular Heterogeneity: Different Expression Profile in Basal-like Versus non-Basal-like Phenotypes. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 15, 536–548 (2018).
12.Urru Silvana Anna Maria et al. Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients. BMC CANCER 18, 56 (2018).
13.Floris Matteo & Olla Stefania. Molecular Similarity in Computational Toxicology. 171–179 (2018) doi:10.1007/978-1-4939-7899-1_7.
14.Floris Matteo, Olla Stefania, Schlessigner David & Cucca Francesco. Genetic-driven druggable target identification and validation. TRENDS IN GENETICS 34, 555 (2018).
15.Steri M et al. Overexpression of the Cytokine BAFF and Autoimmunity Risk. NEW ENGLAND JOURNAL OF MEDICINE 376, 1615–1626 (2017).
16.Maccari Me et al. Severe Toxoplasma gondii infection in a member of a NFKB2-deficient family with T and B cell dysfunction. CLINICAL IMMUNOLOGY 183, 273–277 (2017).
17.Floris Matteo, Raitano G, Medda R & Benfenati E. Fragment Prioritization on a Large Mutagenicity Dataset. MOLECULAR INFORMATICS (2016) doi:10.1002/minf.201600133.
18.Barzaghi Federica et al. Lipopolysaccharide-responsive and beige-like anchor (LRBA) protein deficiency manifesting with lypodistrophy and alps-like phenotype treated with leptin and rapamycin. JOURNAL OF CLINICAL IMMUNOLOGY 36, 293–293 (2016).
19.Zoledziewska Magdalena et al. Height-reducing variants and selection for short stature in Sardinia. NATURE GENETICS 47, 1352–1356 (2015).
20.Maccari Me et al. COMMON VARIABLE IMMUNODEFICIENCY AND EARLY-ONSET AUTOIMMUNE MANIFESTATIONS ASSOCIATED WITH COUPLED MUTATIONS IN NFKB2 AND STAT5A GENES. (2015).
21.DE MIGLIO Maria Rosaria et al. p16INK4a and fascin protein as biomarkers in Triple-negative breast cancer. PATHOLOGICA 107, 152–152 (2015).
22.Piras Is et al. BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT. BONE MARROW TRANSPLANTATION 49, 1400–1404 (2014).
23.Piras Is et al. BAT2 AND BAT3 POLYMORPHISMS AS NOVEL GENETIC RISK FACTORS FOR REJECTION AFTER HLA-RELATED STEM CELL TRANSPLANTATION. TISSUE ANTIGENS 84, 58–58 (2014).
24.Gissi A et al. An Alternative QSAR-Based Approach for Predicting the Bioconcentration Factor for Regulatory Purposes. ALTERNATIVES TO ANIMAL EXPERIMENTATION 31, 23–36 (2014).
25.Floris Matteo et al. A generalizable definition of chemical similarity for read-across. JOURNAL OF CHEMINFORMATICS 6, (2014).
26.Orrù V et al. Genetic Variants Regulating Immune Cell Levels in Health and Disease. CELL 242–256 (2013) doi:10.1016/j.cell.2013.08.041.
27.Fanton M et al. MMsDusty: an Alternative InChI-Based Tool to Minimize Chemical Redundancy. MOLECULAR INFORMATICS 32, 681–684 (2013).
28.Eleuteri C. et al. Drug repositioning and computational analysis for myelin disease regenerative therapies. MULTIPLE SCLEROSIS 19, 74–558 (2013).
29.Carboni N et al. Overlapping syndromes in laminopathies: a meta-analysis of the reported literature. ACTA MYOLOGICA 32, 7–17 (2013).
30.Adenosiland. (2012).
31.Floris Matteo & Stefano Moro. Mimicking Peptides... In Silico. MOLECULAR INFORMATICS 31, 12–20 (2012).
32.Floris Matteo, Sabbadin Davide, Medda Ricardo, Bulfone Alessandro & Moro Stefano. Adenosiland: Walking through adenosine receptors landscape. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 58, 248–257 (2012).
33.Cocco E et al. HLA-DRB1-DQB1 Haplotypes Confer Susceptibility and Resistance to Multiple Sclerosis in Sardinia. PLOS ONE 7, (2012).
34.Vettore S et al. A A386G biallelic GPIb alpha gene mutation with anomalous behavior: a new mechanism suggested for Bernard-Soulier syndrome pathogenesis. HAEMATOLOGICA 96, 1878–1882 (2011).
35.Floris Matteo et al. MAISTAS: a tool for automatic structural evaluation of alternative splicing products. BIOINFORMATICS 27, 1625–1629 (2011).
36.Floris Matteo, Masciocchi J, Fanton M & Moro S. Swimming into peptidomimetic chemical space using pepMMsMIMIC. NUCLEIC ACIDS RESEARCH 39, W261–W269 (2011).
37.Cristiani A et al. ClickMD: an intuitive web-oriented molecular dynamics platform. FUTURE MEDICINAL CHEMISTRY 3, 923–931 (2011).
38.Carboni N et al. Aberrant splicing in lmna gene caused by a novel mutation on the polypyrimidine tract of the intron 5. MUSCLE & NERVE 43, 688–693 (2011).
39.Michielan L, Pireddu L, Floris M & Moro S. Support Vector Machine (SVM) as Alternative Tool to Assign Acute Aquatic Toxicity Warning Labels to Chemicals. MOLECULAR INFORMATICS 29, 51–64 (2010).
40.Floris Matteo et al. A novel mutation in Lamin A/C gene: phenotype and consequences on the protein structure and flexibility. SRX BIOLOGY (2010) doi:10.3814/2010/301679.
41.Mentzen Wi, Floris Matteo & de la Fuente A. Dissecting the dynamics of dysregulation of cellular processes in mouse mammary gland tumor. BMC GENOMICS 10, (2009).
42.Masciocchi J et al. MMsINC: a large-scale chemoinformatics database. NUCLEIC ACIDS RESEARCH 37, D284–D290 (2009).
43.MMsINC. (2008).
44.Floris Matteo, Orsini M & Thanaraj Ta. Splice-mediated Variants of Proteins (SpliVaP) - data and characterization of changes in signatures among protein isoforms due to alternative splicing. BMC GENOMICS 9, (2008).
45.Castrignano T et al. The MEPS server for identifying protein conformational epitopes. BMC BIOINFORMATICS 8, (2007).
46.Carrabino D et al. The mepsMAP server. Mapping epitopes on protein surface: Mining annotated proteins. IEEE TRANSACTIONS ON NANOBIOSCIENCE 6, 155–161 (2007).
47.the chemistry development kit (CDK). (2006).
48.Steinbeck C et al. Recent developments of the Chemistry Development Kit (CDK) - An open-source Java library for chemo- and bioinformatics. CURRENT PHARMACEUTICAL DESIGN 12, 2111–2120 (2006).